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In further announcements, the company revealed that it is to open a dedicated laboratory at its Kakegawa, Japan, site to provide proof-of-concept support and feasibility studies for Catalent's proprietary Zydis Orally Dispersible Tablet (ODT) technology and will also expand manufacturing capacity for its OptiGel Micro softgel technology. Catalent Expands Singapore Clinical Supply Facility for Increased Temperature-Controlled Capabilities. The completion of the second cohort of patients who received 50 million ISC-hpNSC cells, Ginolis Provides Mobidiag High Throughput Manufacturing Lines for Growing Needs of Novodiag Cartridges. Polyplus recently announced the acquisition of e-Zyvec, a provider of DNA design and production services for tailor-made DNA vectors for gene therapy, bio-manufacturing, and research. Ajinomoto Bio-Pharma Services recently announced a strategic supply partnership with the Drugs for Neglected Disease Initiative (DNDi), a collaborative, patients' needs-driven, non-profit drug research and development organization that is developing new treatments for neglected diseases, for the supply of a CpG oligonucleotide, as part of a combination therapy used in the treatment of cutaneous leishmaniasis infections. Resverlogix announces appointment of new chief scientific office national. The first patient in the study was dosed at the Oncological Institute in Chisinau, the capital of Moldova, in Eastern Europe. Novo Nordisk to Acquire Forma Therapeutics & Expand Presence in Sickle Cell Disease & Rare Blood Disorders.
The drug is widely prescribed as first-line therapy for ovarian, breast, lung, and pancreatic cancers. The real answer could help you breathe easier today…. These rAlbumins have been developed and optimized to deliver a safe, stable, and regulatory-compliant product for therapeutic formulations. PDS0101 in combination with KEYTRUDA is being studied in the VERSATILE-002 Phase 2, open-label, multicenter trial for the treatment of recurrent or metastatic HPV16-positive head and neck cancer in collaboration with Merck (known as MSD outside the US and Canada). Catalent Pharma Solutions recently announced the launch of its new FormProRx web tool on November 11, during the 2013 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition. Rain Therapeutics & Roche to Collaborate on Clinical Trial of Milademetan Combination With Anti-PD-L1 Immunotherapy for Various Solid Tumor Indications. DRUG DELIVERY – Tunable Half-Life Extension Based on Recombinant Albumin – Tailoring Pharmaceuticals to Specific Medical Needs. Precision BioSciences, Inc. recently announced program updates across its allogeneic CAR T cell therapy pipeline, including updated data for its Phase 1/2a clinical study of PBCAR0191 with enhanced lymphodepletion (eLD) presented at…. This will require the incorporation of novel biomarkers into innovative clinical trial designs. Drug Discovery Science News | Page 853 | Technology Networks. Promethera Biosciences recently announced a collaboration with EMD Millipore to develop an improved ready-to-use microfluidic perfusion liver assay. The installation and validation of the new equipment extends the company's ability to manufacture creams, ointments, and semi-solids to support clients' clinical trial needs and enables it to efficiently deal with more complex formulations.
Based developer, manufacturer, and supplier of vaccines, recently announced the signing of an agreement for the development, manufacture, and supply of cryogenic vials for Sanaria's malaria vaccine, Sanaria PfSPZ Vaccine. Kintara Therapeutics, Inc. recently announced the US PTO has issued to Kintara United States Patent No. Jim Huang, PhD, reviews how injectable solutions offer an attractive alternative to oral dosage form due to fast onset, reproducible PK/efficacy profile, high bioavailability as a result of bypassing the oral absorption barrier, and suitability of administration under hospital setting. In part 1 of this 3-part series, PharmaCircle, in collaboration with Drug Development & Delivery, focuses on a global review of 2021 product approvals. Chemically, lactose is the disaccharide of the simple sugars D-galactose and D-glucose (Figure 1). Pharma and medical technology specialist Gerresheimer has established small series production at its Technical Competence Center at its Peachtree City, GA, location. Contributor Cindy H. Dubin highlights some of the key players in the market and where they are focusing their efforts to ensure products are of the highest quality, safe, and easy to use. BCC Research reveals in its new report on biologic cancer treatment that access and affordability of cancer treatment options in various countries, along with a rise in the number of cancer incidences due to better diagnostic approaches, will stimulate growth in the global cancer therapeutic market. Three clinical sites for both the MATCH and ALLELE pivotal studies are now open for enrollment in the US and the studies will later expand to additional US sites as well as sites in the EU, Canada, and Australia. Inhibikase Therapeutics Announces FDA has Lifted the Full Clinical Hold on IkT-148009 in Parkinson's Disease. Resverlogix announces appointment of new chief scientific officer перевод. The funding will be used to support commercial development and strengthen CN Bio's position in its key market, the US, whilst also expanding operations across Europe. "Frost & Sullivan's research team has used the findings to select and prioritize the subjects that are deemed to be poised for the greatest growth, ". Studies by others using tamoxifen have demonstrated that density reduction induced by tamoxifen is associated with a significant reduction in breast cancer incidence. Acorda will obtain worldwide rights to CVT-301, a Phase III treatment candidate for OFF episodes of Parkinson's disease (PD).
FDA Approves FENSOLVI for Injectable Suspension for Pediatric Patients with Central Precocious Puberty. UniQure recently announced the completion of patient enrollment in the first dose cohort of a randomized, double-blinded, Phase 1/2 clinical trial of AMT-130 for the treatment of early stage Huntington's disease. "With momentum in patient enrollment in the trials for our lead indications and our recently-reported positive preliminary data in ENPP1 Deficiency, we believe we are another step closer to potentially bringing a much-needed therapeutic option to patients suffering from these devastating diseases, " said Axel Bolte, Caladrius Biosciences Treats First Patient in the Phase 1b Trial for the Treatment of Diabetic Kidney Disease. Another approach is to analyze the changes in the business environment of service providers that support solubilization projects. Resverlogix Announces Appointment of New Chief Scientific Officer - 16.08.2022. 8 billion in the past 3 years that failed to pay off for them. OXB will manufacture lentiviral vectors expressing CTL019/CART-019. Under the agreement, Lilly gains non-exclusive commercial rights for application of the technology to the development of proprietary products. Vascular endothelial growth factor (VEGF) inhibitors dominate the market as they are a safe and effective option to treat age-related macular degeneration (AMD), diabetic macular edema (DME), and retinal vein occlusion (RVO). Under the terms of the agreement, Horizon has licensed to the Partner a novel cell line engineering technology as well as non-exclusive rights to Horizon's proprietary Helitron transposon gene editing technology for an undisclosed financial consideration.
The company's novel approach focuses on targeting hepcidin, a key regulator of iron metabolism, as a treatment for inherited and acquired anemias. Antigen Express, Inc., the company's wholly owned subsidiary, has used this technology platform in the development of self-potentiating immunotherapeutic vaccines for cancer. The study design compares, in a randomized fashion, treatment with CM24 combined with the PD-1 immune checkpoint inhibitor nivolumab and standard of care (SoC) chemotherapy vs. Vaxart, Inc. recently announced it has dosed the first subject in the Phase 2 clinical trial of its oral tablet bivalent norovirus candidate. Robyn M. Resverlogix announces appointment of new chief scientific officer eli lilly. Barfield, PhD, and David Rabuka, PhD, say that despite challenges, there has been progress in advancing complex compounds through clinical trials and successfully treating patients, and these bioconjugate compounds include a subset of molecules known as ADCs. Interim data from individuals in the ongoing Phase 1b clinical trial showed marked activity on multiple individual systemic markers of inflammation, including interleukin-6 (IL-6) and interleukin-8 (IL-8). Taysha Gene Therapies Inc. and Catalent recently announced a partnership to support the development and manufacturing of Taysha's gene therapies at Catalent's Maryland-based gene therapy facilities.
We are passionately growing our business around the combination product value chain through our holistic offering. Ocugen, Inc. recently announced the US FDA agreed to Ocugen's proposed control and overall design for the Phase 3 study of NeoCart, a regenerative cell therapy for the repair of full-thickness lesions of the knee cartilage in adults. The proprietary 6-mL vial incorporates a silicon-based barrier coating system that combines the durability, pH stability, and dimensional consistency of an engineered polymer (such as a cyclic olefin polymer) with the barrier properties and low extractables of silica glass. These funds represent the first closing of a Series B venture financing round, the proceeds from which will be used to advance a series of clinical programs and develop a pipeline of new vaccine products for major diseases using Vaxxas' patented Nanopatch platform. 8, 241, 661 (Biocompatible Film with Variable Cross-Sectional Properties). Celgene & Acceleron Enter Agreement Worth Up to $242 Million. SGS has made this further investment in response to client demand and now possesses comprehensive biomarker testing capabilities across a number of instrument platforms, for both multiplexing and single analyte testing.
The fast-track development laboratory and Gerteis Mini-Pactor represent continuing investment efforts at Metrics to support the changing needs of its contract services clients, Nuvilex, Inc. recently announced it has entered into a stock purchase agreement with Lincoln Park Capital Fund, LLC, a Chicago-based institutional investor. TFF Pharmaceuticals & Augmenta Bioworks Publish Positive In Vivo Data Showing Dry Powder Formulation of COVID-19 Antibody Neutralizes SARS-CoV-2 Infection & Reduces Viral Load. During this latest phase, a $60-million investment will focus on new product solutions, capacity expansion, and additional cGMP manufacturing. 100 Billion of Revenues up for Grabs for Drug Manufacturers by 2020 as Patents for Key Biologics Expire.
In a recent study of five topical metered-dosing dispensers on the market, conducted by Analytical Research Laboratories in Oklahoma City, OK, Topi-CLICK earned top marks. Quotient Sciences and Druggability Technologies recently announced a collaboration to utilize Quotient's integrated Translational Pharmaceutics platform to advance the development of DRGT-46, a novel, fast-acting formulation of celecoxib using proprietary super-API compositions developed by DRGT. These excision products are different from those observed with earlier generations of antisense. Amgen and Allergan plc. The highly effective multiprobe-based capture strategy uses cross-linked chromatin to provide reliable detection and discovery of RNA-associated genomic DNA sequences, RNA sequences, and proteins. Oxygen Biotherapeutics believes adding clinical investigators in India to its existing clinical sites in Switzerland and Israel will enable the company to conclude the study faster and more economically. 6 million shares of common stock and 4. Under the terms of the agreement, Halozyme will receive an initial $23 million payment, followed by milestone payments totaling approximately $130 million for each of up to nine collaboration targets. Hans Ole Klingenberg explains how Bacillus-derived HA offers new opportunities for ophthalmic applications by providing a safe and biocompatible source that can streamline manufacturing processes, while offering convenient application and increased patient comfort and compliance.
The round featured significant new investments as well as participation from all existing institutional investors. He also mentors business and government leaders on the use of technologically innovative tools for better communication with their targeted audiences. "Since our founding in 2007, More Pharma has established a track record of strong growth because of our ability to identify and partner with cutting-edge pharmaceutical technologies, " said Guillermo Ibarra, More Pharma's CEO. By altering and adapting the three main freeze-drying stages to specific formulations, researchers are providing the tools needed for the pharma industry to improve its drug development processes and maintain drug stability when scaling up to production. This approach could enhance the therapeutic effect of current and future therapies and decrease potential systemic toxicity despite systemic administration of the drug. Frost & Sullivan examined promising therapeutics for 2015 finding that oncology, cardiovascular, autoimmune/anti-inflammatories, and infectious diseases will be the top areas of investments in 2015. This 52-week, Phase 2, dose-ranging, open-label study examined the efficacy and safety of seladelpar, a selective peroxisome proliferator-activated receptor-delta agonist, in adults with PBC who were receiving or intolerant to first-line therapy with ursodeoxycholic acid. Anis Rahman, PhD; Scott Frenchek; Brian Kilfoyle; Leena Patterkine, PhD; Aunik Rahman; and Bozena Michniak- Kohn, PhD; use terahertz reflectometry and spectrometry to investigate the permeation kinetics and concentration profile of active ingredients into the stratum corneum. Mustang Bio, Inc. recently announced that the European Medicines Agency (EMA) has granted Priority Medicines (PRIME) designation to MB-107, its lentiviral gene therapy for the treatment of X-linked severe combined immunodeficiency (XSCID) in newly diagnosed infants, also known as bubble boy disease. The acquisition reflects the organization's recent growth, allowing DPT to expand its footprint in Lakewood by adding two buildings totaling 90, 000 square feet of space. In June, 2015 TSI began the HPT-6B. Lykan Bioscience and Vineti recently announced a partnership to unite Lykan's purpose-built cell therapy manufacturing capabilities and Vineti's industry-leading…. Horizon Discovery Group plc recently announced it has entered into a non-exclusive license agreement with ERS Genomics Ltd (ERS) to access intellectual property (IP) relating to the CRISPR/Cas9 gene editing system. The program targets patients admitted to the hospital with hypoxia who do not yet require intensive respiratory support.
What if you could employ a new, patented technology that may make these treatments possible? Get short term trading ideas from the MarketBeat Idea Engine. Palisade Bio, Inc. recently announced the US FDA has granted Fast Track designation to LB1148 for the acceleration of time to return of bowel function following surgery. Caplacizumab is Ablynx's wholly-owned anti-von Willebrand factor (vWF) Nanobody being developed for the treatment of acquired thrombotic thrombocytopenic purpura (aTTP).
GBR 830 is an antagonist of OX40, a costimulatory receptor expressed on T cells mediating T cell activation and survival. Therapeutics Solutions International, Inc. recently announced successful production of a stable microemulsion of Alpha Lipoic Acid (ALA) from ingredients Generally Regarded as Safe (GRAS). The $10-million investment will add 3, 760 square feet of production space to the current facility, providing added flexibility and capacity to the CDMO and its clients. The Phase 2 study (NCT03799718) will enroll progressive MS patients [Expanded Disability Status Scale (EDSS) 3. Loss of functional Beta-cell mass is a core component of the natural history in both types of diabetes — type 1 diabetes (mediated by autoimmune dysfunction) and type 2 diabetes (mediated by metabolic dysfunction).
Avomeen Analytical Services, a full-service independent analytical testing and product development laboratory based in Ann Arbor, MI, recently announced that Mark Harvill has been named its CEO. SEngine Precision Medicine Inc. and Oncodesign recently announced the signature of a research collaboration agreement for R&D of a new personalized cancer treatment for aggressive and….. Cognizant Announces Partnership With Medable to Deliver Strategy, Deployment & Support Services for Decentralized Clinical Trials. 7 variant that initially emerged in the UK and the B.