There are 298 pathogenic genes in CCG gene sequence. And it appears within the sub-category "invigorate the blood and dispel blood stasis", which contains the following formulas: Fatigue, weakness, with pale complexion due to chronic qi and blood deficiency. Xue Fu Zhu Yu Wan may potentially be used, in coordination with a well tailored overall approach, to influence the following conditions: dizziness (vertigo), dysmenorrhea (menstrual pain - cramps), headache, heart disease, hepatitis (b or c), hiccups, hypertension (high blood pressure), insomnia and/or irregular menstruation. Trends Pharmacol Sci. Outcome measurement time points are provided in Table 2. Experimental validation in vitro. Blue Poppy Granule Formulas. The analysis of chemical constituents provides a reference for screening active constituents in XFZYD. Xue fu zhu yu wan while trying to conceive?. Constructing node importance calculation method. The reasons and time for discontinuing will be recorded on CRFs, reported, and analyzed. Increasing research evidence shows that systems pharmacology has the characteristics of integrity and synergy in interpreting the underlying mechanisms of CHM prescription on complex diseases. Important gene network model. Behavioral treatment parameters with primary dysmenorrhea. Persistent daytime drowsiness.
Chinese herbal formula Xuefu Zhuyu for primary dysmenorrhea patients (CheruPDYS): a study protocol for a randomized placebo-controlled trial. We analyzed the enrichment pathways of these CCG and found that the target enrichment pathways of these CCG accounted for 90. Clinical Manifestations.
After 24 h of incubation, 10 μL of CCK8 was added and incubated for a further 4 h. The plate reader was utilized to detect the absorbance at 450 nm. Adverse events will also be reported. In the present work, three published ADME models, OB, Caco-2 and DL, were used to pick out the active compounds. Chapter 8: Assessing risk of bias in included studies. They contain no additives, artificial colors or sugar. Chinese Journal of Hospital Pharmacy(12), 1080–1082. It includes features such as the nature of the disease, cause, location, and development trends [8]. Uncovering the potential mechanism of Xue Fu Zhu Yu Decoction in the treatment of intracerebral hemorrhage | BMC Complementary Medicine and Therapies | Full Text. Increasing evidences confirmed that the PI3K-Akt signaling pathway (hsa04151), JAK-STAT Signaling pathway (hsa04630), NF-kappa B signaling pathway (hsa04064), and IL-17 signaling pathway (hsa04657) respond to these functional modules. Participants in the experimental group will take XFZY orally three times per day (20 ml each dose) for 14 days before the onset of menstruation. Accessed 14 Jan 2020. Compared with control group, the cell viability of OGD groups were significantly reduced.
The GPHCM Department of Scientific Research and the Office of National Key Technology R&D Program for the Thirteen Five-year Plan of the Ministry of Science and Technology, China, will inspect the trial. Pain of all types from qi and blood stagnation - often combined with other more systemic formulas based on the individual. Dysmenorrhea can be classified into primary dysmenorrhea (PD) and secondary dysmenorrhea, with the former more prevalent in young women [2]. Assessment of chronic pain. In addition to participant self-report, physicians will inquiry the participants to seek and record any AEs that happened in the duration of the trial. Xue fu zhu yu tang wan. Gao Y, Wang KX, Wang P, Li X, Chen JJ, Zhou BY, Tian JS, Guan DG, Qin XM, Lu AP. Construction of weighted pathogenic gene–gene interaction network for hypertensive cerebral hemorrhage. We believe that this research will provide important evidence regarding the use of XFZY to treat dysmenorrhea. Xue-Fu-Zhu-Yu capsule in the treatment of qi stagnation and blood stasis syndrome: a study protocol for a randomised controlled pilot and feasibility trial. Quercetin is the main compound of HL and has a wide range of biological activities. Batch is made at a gmp facility and tested by U. S. laboratories!
Nucleic acids research, 42(Web Server issue), W32–W38. The PPI data was extracted from seven published database, include STRING [13], BioGRID, HPRD, Dip, Intact, Reactome and Mint. Selection of active compounds. 11% of effective proteins and are selected as CCG (Fig. Kaysville, UT, USA). Blue Poppy Topicals/Externals. Tiger & Lion Warmer. Found that butyl-phthalide can significantly reduce the neurological deficit in rats with intracerebral hemorrhage, which may be ascribed to butyl-phthalide by up-regulating the expression of VEGF and Ang-2 protein and increasing the density of neovascularization around hematoma without increasing the risk of hematoma enlargement. Xue fu zhu yu tang wan asia link. In the second step, potential CCG are reversely screened based on the core proteins or functional proteins, and further pathway enrichment analysis is performed on the functional compound group for verification. AcuTek Gold Plated Needles.
Chin J Front Med Sci (Electronic Version). Xue Fu Zhu Yu Wan, Herbal Times®. TCMID: Traditional Chinese Medicine integrative database for herb molecular mechanism analysis. To analyze the factors affecting the outcome change at each time point, either a mixed-effects or a linear or logistic regression model will be performed adjusting for baseline characteristics such as age, menstrual pain severity, cumulative painkiller consumption, and other variables. Teas & Therapeutic Foods.
Warning: Prohibited. 49%, which confirmed that the predicted CCG had higher disease coverage rate. Hair loss on the head and body. Finally, the CCG and their targets were used to figure out the underlying mechanisms of XFZYD in treating ICH.
Discontinue use if allergic reaction occurs. The transport rates (nm/s) of compounds in Human intestinal cell line Caco-2 mono layers represent the intestinal epithelial permeability. The PP population will only include participants with neither major protocol deviations nor low compliance. Post traumatic insomnia. 72% of pathogenic gene enrichment pathways (Fig. OGD model is a common model of cerebral hemorrhage and cerebral infarction in vitro by simulating the situation of stroke. Found that the expression of c-myc is related to oxidative stress and neuronal apoptosis after intracerebral hemorrhage [26]. Vomiting after intake of water. After ADME screening, due to its high concentration and high biological activity, some compounds which did not meet the three screening criteria were also kept as the active compounds. Xue Fu Zhu Yu Wan | Drive out Stasis in the Mansion of Blood | Modern Herb Shop. Immune System Support. The statements on this website and all affiliates have not been evaluated by the FDA. Depression or low spirits with a sensation of warmth in the chest. This pathway plays an important role in the treatment of cerebral hemorrhage.
The pharmacopoeia of the People's Republic of China 2015 edition. Qi and/or blood deficiency w/irregular pluse or palpitations (Zhi Gan Cao Tang)…. At present, no trial has compared XFZY for PD to a placebo. CCG: Key group of effective compounds. With Zhi Ke and Jie Geng, expands the chest and promotes Qi movement which circulates Blood.
XFZY's components include Persicae semen (Taoren), Carthami flos (Honghua), Rehmanniae radix (Dihuang), Angelicae sinensis radix (Danggui), Chuanxiong rhizome (Chuanxiong), Paeoniaeradix rubra (Chishao), Achyranthis bidentatae radix (Niuxi), Platycodonis radix (Jiegeng), Bupleuri radix (Chaihu), Aurantii fructus (Zhiqiao) fried with bran, and Glycyrrhizae radix et rhizome (Gancao). Achyranthes bidentata Blume can enhance blood circulation, clear channels, remove blood stasis and relieve pain, and lead blood downward. The node with the degree which is greater than the average degree of all nodes in the network is considered to play a key role in the network structure and can be regarded as a central node. DSMC: Data and Safety Monitoring Committee. Using weighted pathogenic gene–gene interactions and C-T network to construct compounds-targets-pathogenic genes (C-T-P) network. A novel chemometric method for the prediction of human oral bioavailability. Thus, it can be inferred that XFZY can treat the pathogenesis of QBP. For example, leukocyte activation involved in inflammatory responses (GO:0, 002, 758), the production of molecular mediators involved in inflammatory responses (GO:0, 070, 498), and inflammatory responses to antigen stimulation (GO:0, 031, 349). Statistical analysis will be performed by qualified statisticians who are independent from the research team and are blinded to treatment allocation. It is often accompanied by diarrhea, nausea and vomiting, fatigue, dizziness, headache, or even syncope and fever. XFZY is composed of 11 herbs: peach kernel, safflower, Rehmannia glutinosa, ligusticum chuanxiong, red peony root, radix platycodonis, radix platycodonis, radix bupleurum, bran fried fructus aurantii, licorice, and Angelica sinensis. Last updated on Mar 18, 2022. It comes as both an oral liquid and a capsule [15]. All personal information about potential and enrolled participants will be confidential.
One bottle lasts users 11 to 17 days. Studies have shown that PI3K is an important phosphatidylinositol kinase, which involve in cell growth and bone remodeling, and is an important anti-apoptosis regulator. Polycystic ovary syndrome. Consent for publication. 05), while pathogenic genes can be enriched to 195 pathways (p < 0.